24 days old

Process Development Associate

Cambridge, MA 02138
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Job ID: R-104850
Location: Cambridge, MA, US

Amgen is seeking candidates for the role of Process Development Associate at its Cambridge, MA site. This position contributes towards Drug Substance Process Development for late stage clinical and commercial biologics programs, including the development, characterization, and scale-up of upstream and downstream manufacturing processes supporting Ph II/III clinical trials to marketing application. This role is within an integrated organization in which cell culture and purification scientists work together to advance Amgen's rich and dynamic pipeline. With Amgen's biology first approach, the position provides a unique opportunity to work on multiple modalities, from antibodies to oncolytic viruses to bi-specifics.

The successful candidate will help design and perform experiments at the bench scale that span the end-to-end Drug Substance process, from cell culture to purification operations. The candidate will apply established platform approaches and utilize problem-solving skills to rapidly solve day-to-day experimental challenges. Additionally, the candidate will utilize out-of-the-box thinking to contribute to technology development. Finally, the candidate will also demonstrate the desire to expand and develop expertise in both cell culture and purification, thereby further contributing to the integrated group. The candidate will join a diverse team with varied levels of experience and report to a Process Development Senior Scientist.

Key Activities for the Process Development Associate include:
  • Contributing within a project team on goals such as improving process yield and robustness, and scaling-up processes to manufacturing sites
  • Performing small-scale bioprocess experiments that encompass both upstream (cell culture) and downstream (purification) operations
  • Cell culture responsibilities may include maintaining cultures in shake flasks, culture bags, and benchtop bioreactors
  • Purification experiments include, but are not limited to, protein chromatography, filtration, and UF/DF operations
  • Automation programming for benchtop bioreactors, chromatography systems, and robotic liquid handling systems
  • Experimental design and data interpretation, leveraging in-house visualization and analytics tools
  • Communication of findings through oral presentations and written documentation (technical reports as well as GMP documents to support regulatory filings)
  • Providing scientific technical support for technology transfer of processes to manufacturing sites

Basic Qualifications:

Bachelor's degree
Associate's degree and 4 years of Process Development experience
High school diploma / GED and 6 years of Process Development experience

Preferred Qualifications:
  • Bachelor's degree in Chemical, Biomedical, or related Engineering; Life Sciences; or other relevant sciences
  • Experience and demonstrated interest in laboratory work, particularly hands-on experience with mammalian cell culture and/or purification operations.
  • Basic understanding of cell culture, protein chromatography, and filtration principles
  • Demonstrated ability to identify and solve problems by applying scientific and engineering principles, preferably in a process development environment
  • Demonstrated success working with diverse team members in a dynamic, cross-functional environment
  • Familiarity with design of experiments and statistical analysis of data
  • Motivated self-starter with strong communication, interpersonal, organizational skills
  • A desire to learn

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.


Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Posted: 2020-10-01 Expires: 2020-11-02

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Process Development Associate

Cambridge, MA 02138

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